The students fear getting vaccinated, resulting in Nurse Gazelle using a blowpipe to inject them. Unfortunately, she accidentally hits Adam with Jake's inoculation; he seems fine at first, but ends up regressing into a dumb ape.
1x2 - Animal Testing
A high score in the school placement test puts Adam in the honors class where he is teased by the students at first, but he is soon respected by them when they see his excellent spelling skills.
1x3 - Lyon of Scrimmage
Coach Gills teams Adam and Jake as one player for the Charles Darwin middle school football team when Adam displays excellent memory at the game play and Jake displays his good arm for tossing.
1x4 - Bad News Bear
After Adam and Jake break a fish tube, Jake's consequence is to work in the school office filing papers, while Adam's punishment is to guide an endangered panda, Dingbang, around the school.
1x5 - Chew on This
After Adam complains about the cafeteria food, Principal Pixiefrog replaces the animal food with human food which causes the animals to get fat from the unhealthy human foods that are supplied.
1x6 - The 'A' Word
Jake is offended after Adam complains that Bull Sharkowski "went ape" on him, so Adam tries to make up to Jake, though Jake keeps refusing the apologies.
1x7 - Shark Attack
When Adam accidentally hits resident Bull Sharkowski's snout, he is dubbed as the new school bully.
1x8 - Me Adam, You Jake
Mrs. Chameleon thinks that Jake should have the role of Jungle Guy but Adam wants the role also.
1x9 - The Sheds
Slips is shedding his old skin but everyone thinks it is a virus he is spreading around the school called the AAACCCK.
1x10 - Shiny Thing
When Jake finds a diamond doorknob, he discovers its power when all of his classmates (except Adam) become enchanted with the item due to its shining, causing Jake's obsession of his butt to go to far, making all of the students study only monkey butts.
1x12 - Grub Drive
1x13 - Law and Odor
1x60 - 11 Political Animals Guano In 60 Seconds
2x1 - Le Switcheroo
2x2 - I Got a New Aptitude
2x3 - Cheer Pressure
2x4 - Basic Jake
2x5 - The Times, They Are Exchangin
2x6 - Cool Kids
2x7 - Disregarding Henry
2x8 - Nice Moustache
2x9 - Poop Scoop
2x10 - Leaf of Absence
2x11 - I Fear Pretties
2x12 - Magic Fish
2x13 - Ain't Too Proud to Egg
3x1 - Sick Day
3x2 - Cuddlemuffins
3x3 - The Big Field Trip
3x4 - The Spiffanos
3x5 - The Little Mermonkey
3x6 - Diplomatic Insanity
3x7 - Sidekicked
3x8 - Gorilla My Dreams
3x9 - The Prince and the Pooper
3x10 - That Darn Platypus
3x11 - Pride and Pixiefrog
3x12 - The Morning Zoo
Jake fills in for Principal Pixiefrog after he loses his voice.
3x13 - Flesh Fur Fantasy
3x14 - Substitute Sweetheart
3x15 - Don't Noc It 'Til You Try It
4x1 - The Hyena and the Mighty
4x2 - Oh Henry
4x3 - My Feral Lyon
4x4 - A Mid Semester Life's Dream
4x5 - The Ivy League
4x6 - Robo Frog 3000
4x7 - The Notorious Windsor Gorilla
4x8 - Ingrid Through the Out Door
4x9 - Glazed and Confused
4x11 - Mandrill of the House
4x12 - Synch or Swim
4x13 - Lyon's Anatomy
4x14 - Human Behavior
4x15 - Four Eyed Jake
Adam learns that Jake is nearly blind and convinces him to get glasses.